Keyhani A, Booher RJ. 2000 Jul;17(1):119-25. doi: 10.3892/ijo.17.1.119. (2)Department of Pathology, Gunma University Hospital, Maebashi, Gunma, Japan. pleomorphic nuclei Fig. High-grade pleomorphic rhabdomyosarcoma in a 60-year-old male: a case report and review of the literature Fadi Taza , Arjun Kanwal , Mary Zulty and Sadaf Mustafa Department of Medicine, MedStar Union Memorial Hospital, Baltimore, MD, USA ABSTRACT Rhabdomyosarcoma is an aggressivemalignant sof t-tissue sarcoma that develop from undiffer-entiated mesenchymal cells. Optimal treatment remains undefined. Background: Pleomorphic rhabdomyosarcoma (RMS) is a rare sub-type of RMS. The eight women presented with vaginal bleeding, abdominal enlargement, or acute abdomen. Rhabdomyosarcoma in adults is an uncommon tumor that arises mainly in the large skeletal muscles and is usually of pleomorphic histologic subtype. Pleomorphic rhabdomyosarcoma is a rare and aggressive variant of rhabdomyosarcoma (RMS) that usually occurs only in adults aged 45 years or older. Nishijima Y(1), Hirato J(2), Fukuda T(3). In their clinicopathologic study of 38 cases of pleomorphic RMS in adult patients, Furlong et al reported lower extremity as the most frequent site of localization, followed by the trunk [2] . Site: Usually located in the extremities. Primary uterine RMS comprises an even more restricted subset, with little known or reported when compared to most other gynecologic sarcomas. This niuscle and the adjacent soft tibsues wcre rcwc'tc*tl aiitl a split thickness graft applied. As previously mentioned, pleomorphic rhabdomyosarcoma has the worst prognosis with the highest metastatic potential of all the pleomorphic sarcomas (see Table 1) [29,30]. Treatment characteristics and outcomes were analyzed. Malignant neoplasm with large pleomorphic cells exhibiting skeletal muscle differentiation; Diagnostic Criteria . Diagnostic criteria for PRMS by combined histology and currently available immunohistochemistry have not been clearly defined. Malignant neoplasm with large pleomorphic cells exhibiting skeletal muscle differentiation; Diagnostic Criteria. The article discusses a rare case of pleomorphic rhabdomyosarcoma arising in the submandibular gland diagnosed by fine needle aspiration (FNA) cytology and ancillary methods. A therapeutic strategy for pRMS has not been established, and its prognosis remains poor. It is not clear where this variant belong in the current classification of Rhabdomyosarcoma. 22 Fic. PMID: 5686645 [PubMed - indexed for MEDLINE] MeSH Terms Sarcoma classification • At least 50 sarcoma types have been described! Pleomorphic rhabdomyosarcoma is a rare sarcoma type that usually arises in the deep soft tissues of the extremities of older adults [29,30]. Pleomorphic rhabdomyosarcoma arising in the anterior mediastinum: A case report with cytological features of imprint and liquid-based cytology specimens. Rationale: Rhabdomyosarcoma (RMS), a malignant tumor with striated muscle differentiation, is the most common type of soft-tissue sarcoma in children and adolescents, but rarely occurs in adults, and especially in human livers. 1968 Nov;22(5):956-67. Generally round to oval nuclei Hyperchromatic with small nucleoli; Occasional rhabdomyoblasts seen in 30% of cases. Rhabdomyosarcoma (RMS) is currently classified into embryonal RMS, including its botryoid and spindle cell variants, alveolar RMS, including a solid variant, and pleomorphic RMS. Cancer. A new human pleomorphic rhabdomyosarcoma cell-line, HS-RMS-1, exhibiting MyoD1 and myogenin Int J Oncol. Unfavorable histologic type 5-year failure free survival rate: ~ 40%; Markedly enlarged pleomorphic cells. 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